Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.
نویسندگان
چکیده
A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 16 13 شماره
صفحات -
تاریخ انتشار 2006